15
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Cat. No. | Product Name | Target | Signaling Pathways |
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T6196 |
PP1
EI 275,AGL 1872 |
Apoptosis; EGFR; Bcr-Abl; Src; c-Kit | Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PP1 (AGL 1872) 是一种选择性有效 Src 家族抑制剂,抑制 Lck 和Fyn,IC50分别为 5 和 6 nM。 | |||
T3935 |
1-Naphthyl PP1
4 -氨基- 1 -叔丁基- 3 -(1' -萘基)吡唑并[3,4 - D]嘧啶,1-NA-PP 1 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
1-Naphthyl PP1 (1-NA-PP 1) 是选择性的src 家族激酶抑制剂,能够抑制 v-Src (IC50:1.0 μM)、c-Fyn (IC50:0.6 μM)、c-Abl (IC50:0.6 μM)、CDK2 (IC50:18 μM) 和 CAMK II (IC50:22 μM)。 | |||
T7371 |
1-Naphthyl PP1 hydrochloride
1-叔丁基-3-(1-萘基)-1H-吡唑并[3,4-D]嘧啶-4-胺盐酸盐,1-NA-PP 1 hydrochloride |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) 是选择性的 src 家族激酶抑制剂,能够抑制 v-Src (IC50:1.0 μM)、c-Fyn (IC50:0.6 μM)、c-Abl (IC50:0.6 μM)、CDK2 (IC50:18 μM)、CAMK II (IC50:22 μM)。 | |||
T2153 |
1-NM-PP1
PP1 Analog II,1 nM-PP1 |
Serine/threonin kinase; CDK; Src | Angiogenesis; Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
1-NM-PP1 (PP1 Analog II) 是一种有效的Src 家族激酶抑制剂,是一种细胞渗透性 PP1 类似物,对 v-Src-as1 与 c-Fyn-as1 的IC50值分别为 4.3 nM、3.2 nM。 | |||
T23176 |
PP 3
|
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
PP 3 是 Src 激酶抑制剂 PP 2 的阴性对照 | |||
T81417 |
PP5-IN-1
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
PP5-IN-1 是一种具有有效性和竞争性的丝氨酸/苏氨酸蛋白磷酸酶-5 (PP5) 抑制剂,具有潜在的抗癌活性,可诱导癌细胞凋亡。 | |||
T21678 |
3MB-PP1
|
PLK | Cell Cycle/Checkpoint |
3MB-PP1是嘌呤类似物,是一种 Polo 样激酶 1 (Plk1) 抑制剂。在表达类似物敏感的 Plk1 等位基因的细胞中,3MB-PP1 通过靶向 Plk1 阻断有丝分裂进程和细胞分裂。3MB-PP1 特异性抑制类似物敏感的 Ssn3 (Cdk8)。3MB-PP1 抑制 Leu93 突变 Zipper-interacting protein kinase(Leu93-ZIPK),IC50为2 μM。3MB-PP1 可用于细胞分裂和白色念珠菌 (Candida albicans) 菌丝形成的研究。 | |||
T41113 |
3BrB-PP1
3BrB-PP1 |
||
3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase. It is effective in inhibiting protein kinase with mutations in the ATP-binding pocket, specifically the mutation of Thr97 within Sty1's ATP-binding pocket. | |||
T60718 | 3-IN-PP1 | ||
3-IN-PP1是一种针对蛋白激酶D(PKD)家族成员PKD1、PKD2和PKD3具有高效抑制作用的抑制剂,IC50值分别为108、94和108 nM。此外,3-IN-PP1作为一种广谱抗癌剂,能抑制多种肿瘤细胞的生长,适用于癌症研究领域。 | |||
T63259 | PP2A Cancerous-IN-1 | ||
PP2A Cancerous-IN-1 是强效的 CIP2A(Cancerous inhibitor of PP2A) 和 p-Akt 抑制剂,表现出强大的抗增殖作用。 | |||
T21041 |
Hydralazine
Apresolin,Aprezolin,Apressin |
||
Poly(1-decene), a thermoplastic belonging to the class of polyolefins, may be used to estimate the pour point (PP) properties of palm oil methyl esters. | |||
T76538 |
Pancreatic polypeptide
|
||
Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽,具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。 | |||
T79878 |
Hydroxy-PP-Me
|
Apoptosis | Apoptosis |
Hydroxy-PP-Me为一特异性CBR1抑制剂,IC50值为759 nM。该化合物能够抑制血清戒断所诱导的细胞凋亡(apoptosis)。与As2O3单独应用相比,Hydroxy-PP-Me可增强As2O3引发的凋亡细胞死亡效果。 | |||
T74359 | PP-C8 | ||
PP-C8 是一种有效的选择性 PROTACCDK12-Cyclin K 降解剂。PP-C8 诱导 CDK12-Cyclin K 降解,对 CDK12 和 Cyclin K 的DC50分别为 416 和 412 nM。PP-C8 与PARP 抑制剂在三阴性乳腺癌 (TNBC) 中具有高效的协同抗增殖作用。 | |||
T36864 |
GRP (human) (trifluoroacetate salt)
|
||
Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-depend... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70725 | Motuporin | ||
Motuporin is an inhibitor of type-1 and type-2A protein phosphatase catalytic subunits (PP-1c and PP-2Ac). | |||
T23421 | Tautomycetin | Others | Others |
protein phosphatase (PP)1 inhibitor |